Searchable abstracts of presentations at key conferences in endocrinology

ea0098t6 | Trials In Progress | NANETS2023

Genetic profiling in the randomized controlled phase 3 COMPOSE trial of 177Lu-edotreotide for well-differentiated aggressive grade 2/3 gastroenteropancreatic neuroendocrine tumors

Halfdanarson Thorvardur R. , Capdevila Jaume , Halperin Daniel M. , Herrmann Ken , Kong Grace , Mailman Josh , Reidy-Lagunes Diane , Srirajaskanthan Raj , Sierras Cristina , Rotger Amanda

Background: Targeted radionuclide therapies (TRTs) have changed the treatment paradigm of neuroendocrine tumors (NET) and are expected to be widely available for patients with various gastroenteropancreatic (GEP)-NET phenotypes. However, while they have great potential, TRT-based therapeutic strategies for high-grade GEP-NET demonstrate variable outcomes, and there is a current lack of tools to identify patients who are likely to respond to TRT. To address this need, the rando...